Preheat oven to 375°F. Bring a large pot of salted water to boil and cook ziti pasta according to package directions until 2 minutes before al dente. Drain and set aside.
In a large mixing bowl, combine cooked ziti with marinara sauce, Alfredo sauce, ricotta cheese, fontina cheese, 1 cup mozzarella, 1/4 cup Parmesan, and Romano cheese. Mix gently until pasta is evenly coated.
Transfer mixture to a greased 9x13 baking dish and spread evenly. In a small bowl, combine remaining 1 cup mozzarella, remaining 1/4 cup Parmesan, panko breadcrumbs, minced garlic, and melted butter.
Sprinkle cheese and breadcrumb mixture evenly over pasta. Bake uncovered for 30-35 minutes until top is golden brown and bubbly.
Remove from oven and let rest for 5 minutes before serving. Garnish with fresh parsley if desired. Serve hot.